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Background

The-Research-Annex

The Desmond and Leah Tutu Research Annex

The Research Annex was built adjacent to the Masiphumelele Clinic in 2004, in order to host the Comprehensive International Programme for Research on AIDS – South Africa (CIPRA-SA) study. The CIPRA-SA projects one and three were managed from this site from 2004 – 2010.

CIPRA-SA Project 1 recruited 363 adults starting antiretroviral treatment (ART) and randomised them to be cared for by either a nurse practitioner or a doctor and found that nurse-care was non-inferior to doctor care over 96 weeks. This study was published in the Lancet and informed the current South African ART programme of nurse-based care.

CIPRA-SA Project 3 was the first study to show the benefit of a high coverage ART programme on the incidence and prevalence of population tuberculosis (TB) rates. The ongoing molecular epidemiological studies, initiated by this project, have also provided insights into TB transmission dynamics in this high burdened community, and highlighted the importance of including HIV-negative patients in TB interventions.

We have worked closely with the Masiphumelele Clinic team since 2000, providing clinical and pharmacy support over the last decade. The DTHF manages the City of Cape Town reporting for the 1200 people Masiphumelele ART service. In addition, we provide counselling staff for the roll-out of chronic adherence clubs and staff support for the TB clinic

The Masiphumelele Research Offices

This research block was procured serendipitously as transferable temporary accommodation from the Cape Town based 2010 Soccer World Cup where they had been used for the press corps. Transferred in units and reconfigured on the DTHF property behind the DTHF Youth Centre, these double story units have easily and very cost effectively afforded a wonderfully versatile clinical research site. The final stage of weather-proofing with a roof and side walls has further enhanced this research site and in November 2014, most of the women’s’ prevention research moved from the Desmond and Leah Tutu Research Annex to join the aerobiology TB research group at this site.

Current Trials

Sponsor: South African Medical Research Council
DTHF PI: Prof Robin Wood
Site: Desmond and Leah Tutu Research Centre
Status: Recruiting

CO2 monitoring studies

Current research efforts include investigating where TB transmission may occur to adolescents and adults.  In collaboration with the UCT Department of Electrical Engineering we have developed an innovative approach to the study of TB transmission: using measurements of individual-based environmental CO2 monitoring to determine rebreathed litres of air as a surrogate measure of risk of TB infection. Prof Wood is currently leading studies to identify community locations of potential TB transmission risk among adolescents and adults, utilizing these C02 measurements.

Sponsor: DTHF, Royal Society, Bill and Melinda Gates Foundation
DTHF PI: Dr Keren Middelkoop
Site: Desmond and Leah Tutu Research Centre
Status: Recruiting

TB Molecular epidemiological study

Observational studies in which all TB patients are invited to participated. The study uses a combination of notification data, patient interviews, and genotyping of the TB bacterium to investigate the ongoing, longterm impact of the ART program on TB rates and to continue to explore TB strain diversity and transmission in this community, including the changes through time in the clustering and transmission of TB disease among HIV-positive and HIV-negative individuals

Sponsor: DTHF, Royal Society, Bill and Melinda Gates Foundation
DTHF PI: Prof Linda-Gail Bekker
Site: Desmond and Leah Tutu Research Centre
Status: Not Yet Recruiting

Cardiovascular Disease Risk Factors in ART-experienced Cohort

An observational study assessing the frequency and severity of six CVD risk factors in an established, prospective cohort of ART-experienced HIV-infected patients.

Sponsor: South African Medical Research Council, Bill and Melinda Gates Foundation
DTHF PI: Prof Robin Wood
Site: The Masiphumelele Research Offices
Status: Not Yet Recruiting

Controlled Collection of Aerosolized Mycobacterium Particles

The purpose of this Research Study is to investigate airborne aerosolized Mycobacterium particles expelled by infectious TB patients. It aims to understand how these TB particles differ when being collected by means of air versus collected by means of culture and to explore TB organism adaption to particle size and environmental stress. The research team also hopes to also characterise the nature of the TB organism and thus identify specific points that can be exploited to interrupt and reduce the spread of TB.

Sponsor: IPM
DTHF PI: Dr Katherine Gill
Site: Desmond and Leah Tutu Research Centre
Status: Recruiting

IPM 027

A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Phase 3 Safety and Effectiveness Trial of a Vaginal Matrix Ring Containing Dapivirine for the Prevention of HIV-1 Infection in Women

More Info: Click Here

Sponsor: CONRAD
DTHF PI: Prof Linda-Gail Bekker
Site: Desmond and Leah Tutu Research Centre
Status: Active - Not Recruiting

FACTS001

Multi-Center, Randomized, Double-Blind, Placebo-Controlled Phase 3 Safety and Effectiveness Trial of Tenofivir Vaginal Gel for the Prevention of HIV-1 Infection in Women

More Info: Click Here

People

Robin Wood
Robin Wood

Principal Investigator

Linda-Gail Bekker

Principal Investigator

Catherine Orrell
Catherine Orrell

Associate Professor

Carl Morrow

Principal Scientific Officer

Fezeka Miti

TB Clerk

Keren Middelkoop

Senior Research Officer

Daphne Moralie

Grant and Project Administrator

Katherine Gill

Medical Officer

Contact

The Desmond and Leah Tutu Research Annex

Desmond and Leah Tutu Research Annex: 021 785 5486
Dr Keren Middelkoop: 021 650 6960

Physical Address:
Masiphumelele Community Health Centre
Pokela Rd, Masiphumelele
Cape Town

Masiphumelele Research Offices

Tel: 021 785 3121

Physical Address:
Guinea Fowl Road
Sunnydale
Cape Town