Linda-Gail BekkerPrincipal Investigator

Danielle CridaSenior Site Investigator

Avril MastersClinical Site Manager


The prevention division is involved in researching new and more effective ways to prevent HIV, TB, HPV and other infections. Having started as an HIV vaccine unit in 2005, the division has accumulated expertise in biomedical technologies such as antiretroviral pre-exposure prophylaxis, microbicides and other vaccines, including tuberculosis and human papilloma virus prophylactic vaccines. The site also has considerable expertise in social and behavioural aspects of prevention, community engagement and community information dissemination.

In addition, the site provides HIV counselling and testing, sexual and reproductive health services and health screens to a large number of potential, past and current participants.



The prevention division operates from a state of the art, custom built clinical trial site known as Emavundleni Research Centre in Sonwabile Road, Crossroads, Cape Town. This clinic is able to accommodate large numbers of participants in phase 1-3 trials and a large team of highly trained individuals conduct trials to international standards. Participants are drawn from the surrounding Klipfontein/Mitchells Plain Sub district and are able to engage in the many exciting programs on offer at Emavundleni. There is no charge for participation.


A wide range of volunteers are needed for diverse prevention protocols- adolescents are invited to participate in TB pre-infection vaccine studies and HPV vaccine studies, women and men are encouraged to take part in PrEP and vaccine studies and women are involved in ring, gel and long acting PrEP studies.

All protocols are reviewed and approved by the South African Medicine Control Council and the Human Research Ethics Committee of the University of Cape Town.


The site is actively engaged in clinical research associated with the UCT Clinical Trials Unit. This involves collaborations with the HIV Vaccine Trials Network, HIV Prevention Trials Network and the Microbicide Trials Network. The site also collaborates with a number of other organisations sponsoring clinical prevention research.

Current studies include HIV prophylactic vaccines, TB pre-infection vaccines, HPV vaccines, Vaginal Ring microbicide studies, long acting PrEP studies.


Avril Masters –